GrippeAllemagneV3, Main, Exploration, bibRecord, 000461

Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe.

Identifieur interne : 000461 ( Main/Exploration ); précédent : 000460; suivant : 000462

Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe.

Auteurs : Elmi N. Zainuddin [Allemagne] ; Renate Mentel ; Victor Wray ; Rolf Jansen ; Manfred Nimtz ; Michael Lalk ; Sabine Mundt

Source :

Journal of natural products [ 0163-3864 ] ; 2007.

RBID : pubmed:17602586

Descripteurs français

KwdFr :
- Allemagne, Antiviraux (), Antiviraux (isolement et purification), Antiviraux (pharmacologie), Concentration inhibitrice 50, Depsipeptides (), Depsipeptides (isolement et purification), Depsipeptides (pharmacologie), Microcystis (), Résonance magnétique nucléaire biomoléculaire, Structure moléculaire, Virus de la grippe A ().
MESH :
- isolement et purification : Antiviraux, Depsipeptides.
- pharmacologie : Antiviraux, Depsipeptides.
- Allemagne, Antiviraux, Concentration inhibitrice 50, Depsipeptides, Microcystis, Résonance magnétique nucléaire biomoléculaire, Structure moléculaire, Virus de la grippe A.
Wicri :
- geographic : Allemagne.

English descriptors

KwdEn :
- Antiviral Agents (chemistry), Antiviral Agents (isolation & purification), Antiviral Agents (pharmacology), Depsipeptides (chemistry), Depsipeptides (isolation & purification), Depsipeptides (pharmacology), Germany, Influenza A virus (drug effects), Inhibitory Concentration 50, Microcystis (chemistry), Molecular Structure, Nuclear Magnetic Resonance, Biomolecular.
MESH :
- chemical , chemistry : Antiviral Agents, Depsipeptides.
- chemical , isolation & purification : Antiviral Agents, Depsipeptides.
- chemical , pharmacology : Antiviral Agents, Depsipeptides.
- geographic : Germany.
- chemistry : Microcystis.
- drug effects : Influenza A virus.
- Inhibitory Concentration 50, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular.

Abstract

Bioassay-guided isolation of antiviral compounds from the cultured cyanobacterium Microcystis ichthyoblabe provided two novel cyclic depsipeptides, ichthyopeptins A (1) and B (2). Their structures were determined by 1D (1H and 13C) and 2D (COSY, TOCSY, ROESY, HMQC, and HMBC) NMR spectra, ESIMS-MS, and amino acid analysis. The fraction containing both cyclic depsipeptides exhibited antiviral activity against influenza A virus with an IC50 value of 12.5 microg/mL.

DOI: 10.1021/np060303s
PubMed: 17602586

Affiliations:

Allemagne

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000465
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Le document en format XML

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<author><name sortKey="Zainuddin, Elmi N" sort="Zainuddin, Elmi N" uniqKey="Zainuddin E" first="Elmi N" last="Zainuddin">Elmi N. Zainuddin</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Pharmacy, Friedrich-Ludwig-Jahnstrasse 17, Ernst-Moritz-Arndt University, D-17487 Greifswald, Germany.</nlm:affiliation>
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<author><name sortKey="Mentel, Renate" sort="Mentel, Renate" uniqKey="Mentel R" first="Renate" last="Mentel">Renate Mentel</name>
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<author><name sortKey="Wray, Victor" sort="Wray, Victor" uniqKey="Wray V" first="Victor" last="Wray">Victor Wray</name>
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<author><name sortKey="Lalk, Michael" sort="Lalk, Michael" uniqKey="Lalk M" first="Michael" last="Lalk">Michael Lalk</name>
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<term>Depsipeptides (chemistry)</term>
<term>Depsipeptides (isolation & purification)</term>
<term>Depsipeptides (pharmacology)</term>
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<term>Influenza A virus (drug effects)</term>
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<term>Depsipeptides ()</term>
<term>Depsipeptides (isolement et purification)</term>
<term>Depsipeptides (pharmacologie)</term>
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<term>Structure moléculaire</term>
<term>Virus de la grippe A ()</term>
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<term>Résonance magnétique nucléaire biomoléculaire</term>
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<Abstract><AbstractText>Bioassay-guided isolation of antiviral compounds from the cultured cyanobacterium Microcystis ichthyoblabe provided two novel cyclic depsipeptides, ichthyopeptins A (1) and B (2). Their structures were determined by 1D (1H and 13C) and 2D (COSY, TOCSY, ROESY, HMQC, and HMBC) NMR spectra, ESIMS-MS, and amino acid analysis. The fraction containing both cyclic depsipeptides exhibited antiviral activity against influenza A virus with an IC50 value of 12.5 microg/mL.</AbstractText>
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Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe.

Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki